| 无锡-常州地下水中内分泌干扰物的赋存特征和健康风险评价 |
| 摘要点击 2763 全文点击 774 投稿时间：2020-05-11 修订日期：2020-07-12 |
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| 中文关键词 内分泌干扰物 无锡-常州地区 地下水 赋存特征 健康风险 |
| 英文关键词 endocrine disrupting chemicals Wuxi-Changzhou groundwater occurrence characteristics health risk |
| 作者 | 单位 | E-mail | | 王淑婷 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 | shuting0429@163.com | | 饶竹 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 | | | 郭峰 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 | fengguo@cags.ac.cn | | 刘成海 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 | | | 战楠 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037 | | | 王娅南 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037
贵州医科大学公共卫生学院, 贵阳 550025 | | | 彭洁 | 中国地质科学院国家地质实验测试中心, 自然资源部生态地球化学重点实验室, 北京 100037
贵州医科大学公共卫生学院, 贵阳 550025 | | | 杨鸿波 | 贵州医科大学公共卫生学院, 贵阳 550025 | |
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| 中文摘要 |
| 采用固相萃取-超高效液相色谱串联质谱法（SPE-UPLC-MS/MS）分析了无锡-常州地区地下水中4类（性激素、孕激素、糖皮质激素和酚类激素）22种典型内分泌干扰物（EDCs）的赋存特征.结果表明，共有20种EDCs被检出，以双酚A（BPA）、雌酮（E1）、雌二醇（E2）和炔雌醇（EE2）为主，检出率均在90%以上，其次是雌三醇（E3）和甲基泼尼松龙（Meprednl），检出率分别为67.7%和48.4%.BPA平均浓度最高，为4.95 ng·L-1，其次是甲基泼尼松龙、雌二醇、泼尼松龙（Prednl）、丙酸睾酮（TES-pro）和醋酸甲地孕酮（MA），平均浓度分别为2.84、0.71、0.64、0.58和0.53 ng·L-1.各点位总浓度范围在0.38~147.35 ng·L-1之间，高浓度点主要集中在常州市新北区、溧阳市和钟楼区.结合主成分分析（PCA）和采样点周边污染源对潜在来源进行解析，结果表明地下水中EDCs主要来源于生活污水、养殖和工业废水，其次为医疗废水.非致癌健康风险评价结果表明，研究区地下水中EDCs非致癌风险整体处于较低水平，饮水途径引起的风险水平大于皮肤暴露，EE2的非致癌风险最高，应作为重点监控对象. |
| 英文摘要 |
| The concentrations of 22 endocrine disrupting chemicals, including 4 categories of sex hormones, progesterones, glucocorticoids, and phenolic hormones, in groundwater of Wuxi-Changzhou were analyzed using solid-phase extraction and ultra-performance liquid chromatography tandem mass spectrometry. The results indicated that 20 EDCs were detected, among which bisphenol A (BPA), estrone (E1), estradiol (E2), and 17α-ethinyl estradiol (EE2) were the main components with detection ratios greater than 90%, followed by estriol (E3) and methyl-prednisolonel (Meprednl), which had detection rates 67.7% and 48.4%, respectively. The average concentration of BPA was the highest (4.95 ng·L-1), followed by that of Meprednl, E2, prednisolone (Prednl), testosterone propionate (TES-pro), and megestrol-acetate (MA; 2.84, 0.71, 0.64, 0.58, and 0.53 ng·L-1, respectively). The total concentration in each site ranged from 0.38 to 147.35 ng·L-1. The sites with higher concentration were mainly distributed in the Xinbei District, Liyang City, and the Zhonglou District of Changzhou City. The potential sources were analyzed by a principal component analysis (PCA) combining the point sources near sample sites. The results showed that domestic sewage, aquaculture, and industrial wastewater were the main sources, following by medical wastewater. A non-carcinogenic risk assessment showed a low risk of EDCs in the groundwater of the study area, and the risk of drinking water was greater than that of skin exposure. EE2 had the highest non-carcinogenic risk and is suggested to be monitored in priority. |
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