| 生产源区人血清中六溴环十二烷水平与甲状腺激素相关性研究 |
| 摘要点击 1650 全文点击 916 投稿时间：2014-03-24 修订日期：2014-05-05 |
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| 中文关键词 六溴环十二烷 人血清 甲状腺激素 生产源区 相关性 |
| 英文关键词 hexabromocyclododecane(HBCD) human serum thyroid hormone production source region correlation |
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| 中文摘要 |
| 采用超高效液相色谱-电喷雾离子源-串联三重四极质谱（UPLC-ESI-MS/MS）检测了六溴环十二烷（HBCD）在生产源区人血清中的浓度. 80个人血清样品中ΣHBCD含量（以脂重计，下同）为nd~2702.5 ng ·g-1，均值和中值分别为104.9 ng ·g-1和5.9 ng ·g-1，其中42个样品中γ-HBCD丰度最高，26个样品中α-HBCD丰度最高. ΣHBCD浓度与年龄、性别无显著性相关. 本研究中，生产源区人群血清甲状腺5项指标异常率高达33%. 且检出HBCD异构体的人血清样本中TSH、T3、FT3、T4及FT4这5项指标出现异常的概率显著高于未检出HBCD的血清样本. 本研究认为生产源区居民属于HBCD高暴露人群，人群暴露HBCD可能会显著增加甲状腺五项指标异常的发生率. |
| 英文摘要 |
| The levels of hexabromocyclododecane (HBCD) in human serum from the HBCD production source region were detected by UPLC-ESI-MS/MS. The concentrations (lipid weight) of ΣHBCD in 80 serum samples ranged from not detectable to 2702.5 ng ·g-1. The mean and median values were 104.9 ng ·g-1 and 5.9 ng ·g-1, respectively. The most abundant HBCD isomer in 42 samples was γ-HBCD, while α-HBCD was the most abundant isomer in the other 26 serum samples. There was no significant difference in ΣHBCD concentration among different age and gender. In this study, the thyroid hormone abnormality rate in the 80 residents was up to 33%. The thyroid hormone abnormality rate of the residents whose serum HBCD was detected was significantly higher than those without HBCD in serum. Since the local residents were highly exposed to HBCD, the probability of thyroid abnormality might be significantly increased. |
