| 铜对草鱼及花鲢的毒性预测：基于生物配体模型 |
| 摘要点击 2634 全文点击 1893 投稿时间：2014-03-28 修订日期：2014-05-06 |
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| 中文关键词 草鱼 花鲢 生物配体模型 预测 铜 LA50 |
| 英文关键词 Ctenopharyngodon idellus Hypophthalmichthys molitrix biotic ligand model(BLM) prediction copper LA50 |
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| 中文摘要 |
| 试验配置不同胡敏酸浓度（DOC浓度为 0.05、0.5、1、2、4 mg ·L-1）下，分别对草鱼及花鲢进行铜的一系列 96 h生物急性毒性试验，结果表明DOC浓度与 LC50呈正相关关系，此与生物配体模型描述一致. 利用两鱼种（Fathead minnow、Rainbow trout）的生物配体模型预测草鱼及花鲢的LC50，得出平均绝对偏差分别为 591.2、157.14 μg ·L-1及 728.18、91.24 μg ·L-1. 在生物配体模型（biotic ligand model，BLM）铜形态分布平台下，得到草鱼及花鲢的 LA50（以湿重计）依次为 10.960 nmol ·g-1和3.978 nmol ·g-1. 通过校正草鱼及花鲢的 LA50，得出平均绝对偏差依次为 280.52 μg ·L-1和92.25 μg ·L-1，预测性能显著提高. 基于所确立的 LA50，通过搜集草鱼及花鲢的毒性数据，预测其 LC50，得到平均绝对偏差分别为 252.37 μg ·L-1和50.26 μg ·L-1，此证实基于生物配体模型的毒性预测具有一定的实用性. |
| 英文摘要 |
| A series of 96 h copper acute toxicity experiments were conducted with Ctenopharyngodon idellus and Hypophthalmichthys molitrix under different concentrations of DOC [ρ(DOC) 0.05,0.5,1,2,4 mg ·L-1]. Higher DOC resulted in a reduction of toxicity, which was in line with the concepts of the biotic ligand model (BLM). It was concluded that the mean absolute deviation (MAD) of LC50with Ctenopharyngodon idellus and Hypophthalmichthys molitrix was 591.2, 157.14 μg ·L-1 and 728.18, 91.24 μg ·L-1, respectively, by the prediction of copper BLM developed for Fathead minnow and Rainbow trout. Based on speciation analysis of biotic ligand model, it was shown that LA50 values of Ctenopharyngodon idellus and Hypophthalmichthys molitrix were 10.960 and 3.978 nmol ·g-1, respectively. Then the MAD values became 280.52 and 92.25 μg ·L-1 for Ctenopharyngodon idellus and Hypophthalmichthys molitrix using the normalized LA50. Finally by searching toxicity data in literature, the MAD values on Ctenopharyngodon idellus and Hypophthalmichthys molitrix were 252.37 and 50.26 μg ·L-1, successively. This result verified that the toxicity prediction based on biotic ligand model was practical. |
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