| Polybrominated diphenyl ethers(PBDEs) concentrations in 36 resident serum samples from PBDEs production source area were analyzed by gas chromatography/negative chemical ionization/mass spectrometry(GC-NCI-MS) method, and the concentrations of thyroid hormones were determined as well. The 5PBDEs(BDE-28,-47,-153,-183,-209) concentrations(lipid weight) in serum ranged from 130.3 to 4478.4 ng·g-1, with an average value of 529.9 ng·g-1. BDE-209 was a dominant PBDE congener, on average accounting for 69.8% of the total PBDEs concentrations. Spearman rank correlation coefficient was calculated between PBDEs and thyroid hormone, it showed that there were high significant negative correlation between BDE-28, -47, -153, -183 and thyroid-stimulating hormone(TSH), and significant negative correlation was also found between BDE-183 and free thyroxine(fT4). Additionally, there were significant positive correlation between BDE-28, -47 and triiodothyronine(T3), as well as between BDE-28, -153, -183 and free triiodothyronine(fT3). In summary, the concentrations of PBDEs in serum in this study were at a high level, and BDE-209 was the predominant congener. The exposure to the PBDEs may affect thyroid hormone levels, and the further research should focus on the relationship between PBDEs and thyroid hormone concentrations. |
