| 30种离子液体对青海弧菌Q67的毒性效应 |
| 摘要点击 1967 全文点击 1555 投稿时间：2010-04-11 修订日期：2010-06-28 |
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| 中文关键词 离子液体 青海弧菌Q67 毒性效应 微板毒性分析法 烷基链效应 |
| 英文关键词 ionic liquids(ILs) Vibrio qinghaiensis sp.Q67 toxicity microplate toxicity analysis alkyl-chain effect |
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| 中文摘要 |
| 应用微板毒性分析法系统地考察了30种具有不同烷基链长度、阴离子基团和阳离子骨架(甲基咪唑、二甲基咪唑和吡啶)的“绿色溶剂”离子液体(ionic liquids，ILs)对一种新型淡水发光菌青海弧菌Q67 (Vibrio qinghaiensis sp. Q67)的毒性效应.非线性拟合结果表明，Logit或Weibull函数可有效地表征30种ILs的剂量-效应曲线，其相关系数R>0.98，均方根误差RMSE<0.053；30种ILs对Q67的毒性差异很大，pEC50值在1.01～5.48之间；ILs对Q67的毒性具有烷基链效应，且烷基链上每增加2个碳原子，其pEC50值增加近1倍；ILs的阴离子基团、阳离子骨架及ILs本身的吸光性不显著影响ILs对发光菌Q67的毒性. |
| 英文摘要 |
| To systematically and effectively assess the toxic effects of “green solvent” ionic liquid (ILs) to a novel freshwater luminescent Vibrio qinghaiensis sp. Q67 (Q67), the toxicities of 30 ILs with different alkyl chain lengths, anions and cation skeletons (methylimidazolium, dimethylimidazolium and pyridinium) were determined using the microplate toxicity analysis. The observed dose-response curves (DRCs) were fitted by using the nonlinear least square regression. It was shown that the DRCs of 30 ILs could be well described by the Logit or Weibull function(R > 0.98, RMSE < 0.053). The toxicities of 30 ILs varied greatly and the pEC50values of 30 ILs ranged from 1.01 to 5.48. The toxicities of ILs to Q67 mainly depended on the alkyl chain length and every two-carbon augment on the alkyl chain made the toxicity duplicate. The anions, cation skeletons and light absorbance of ILs showed no significant effect on the toxicities of ILs to Q67. |
