| PFOS/PFOA对斑马鱼(Danio rerio)胚胎致毒效应研究 |
| 摘要点击 2875 全文点击 4857 投稿时间：2008-07-08 修订日期：2008-10-16 |
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| 中文关键词 全氟辛酸 全氟辛基磺酸 斑马鱼胚胎 水生毒性 |
| 英文关键词 PFOA PFOS zebrafish embryos aquatic toxicity |
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| 中文摘要 |
| 采用斑马鱼胚胎毒性测试方法，研究了PFOA/PFOS对斑马鱼的急性毒性和生命早期阶段生长发育的影响.结果表明，PFOS/PFOA对斑马鱼有明显毒性作用，LC50(48 h)分别为1005 mg/L和107 mg/L，LC50(96 h)分别为499 mg/L和71 mg/L.PFOS/PFOA抑制斑马鱼胚胎发育，可导致胚胎发育畸形，甚至死亡，高浓度(＞240 mg/L)PFOS损伤细胞膜，导致胚胎分裂中的细胞发生自溶而卵凝结死亡，抑制胚胎原肠胚的形成.在各种亚致死效应中，脊柱畸形对PFOS暴露最敏感，其EC50=9.14 mg/L，PFOA暴露最敏感亚致死性毒理学终点为96 h孵化，对应EC50=328.0 mg/L.PFOA/PFOS导致胚胎发育延迟，具有发育毒性. |
| 英文摘要 |
| Acute toxicity of PFOS/PFOA to zebrafish(Danio rerio) and development effects to zebrafish embryo were examined using a zebrafish embryo test. PFOS/PFOA showed remarkably toxicity effects on zebrafish. The LC50(48 h)values are 1?005 mg/L for PFOA，107 mg/L for PFOS，while the LC50(96 h)values are 499 mg/L for PFOA，71 mg/L for PFOS. Moreover PFOS/PFOA inhibited embryo development, and caused embryo abnormality and death. After exposure to high concentration of PFOS(＞240 mg/L), cells in animal pole of embryos autolyzed to coagulate, which indicated PFOS caused cell membranes damage. The most sensitive endpoints for PFOS exposure is spinal column malformation, and the EC50 values is 9.14 mg/L. While for PFOA hatching (96 h) is the most sensitive, and the EC50 values is 328.0 mg/L. Both PFOS and PFOA retarded embryo development which indicates their development toxicity. |
