| 鱼肉结合态MCLR的亚慢性毒性研究 |
| 摘要点击 1643 全文点击 1247 投稿时间：2007-01-19 修订日期：2007-03-28 |
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| 中文关键词 微囊藻毒素 水产品 亚慢性 毒性 |
| 英文关键词 microcystin aquatic products subchronic toxicity |
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| 中文摘要 |
| 为了揭示含有微囊藻毒素水产品的食用安全性，以雄性BALB/C小鼠为模式生物，通过为期13周的灌胃染毒实验，研究了鱼肉结合态MCLR对小鼠的亚慢性毒性作用，并与水溶态MCLR的毒性进行了对比.结果表明，68.75 μg/kg (以单位体重计)剂量水溶态MCLR可引起小鼠肝脏显著系数增加（P＜0.05），ALT、AST活性增强（P＜0.01），引起肝细胞出现有空泡状病变；而肾脏酶学指标BUN、Cr及肾脏组织病理学观察均未发现明显异常；与之相比，同剂量鱼肉结合态MCLR对小鼠各项指标的影响并不明显，仅在实验第1周出现小鼠肝脏肿大（P＜0.05）、ALT活性增强(P＜0.01).由此推断，鱼肉结合态MCLR的毒性低于水溶态MCLR. |
| 英文摘要 |
| Subchronic oral gavage toxicity of MCLR in water and in fish muscle was examined in male Balb/C mice for 13 weeks to assess the safety of aquatic products. The results showed that the liver coefficient （P＜ 0.05）, the activities of ALT and AST（P＜0.01） increased significantly and distinct centrilobular to midzonal hepatucellular occurred after oral gavage of dissolved MCLR at a dose of 68.75 μg/kg (body weight), but neither influence on the activities of BUN and Cr nor histological changes on kidney were observed at any time point. In contrast, the administration of fish muscle-bound MCLR at the same dose resulted in no obvious subchronic toxicity in mice, except that the increase of liver coefficient（P＜0.05）and the activity of ALT（P＜0.01）can be observed only at the first week. It was concluded that the toxicity of fish muscle-bound MCLR was much lower than that of dissolved MCLR. |
