| 壬基酚对成体玫瑰无须性腺的毒性效应 |
| 摘要点击 1513 全文点击 876 投稿时间：2006-12-19 修订日期：2007-05-29 |
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| 中文关键词 壬基酚 玫瑰无须 精巢 卵巢 毒性 |
| 英文关键词 nonylphenol rosy barb testis ovary toxicity |
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| 中文摘要 |
| 以成体玫瑰无须（Puntius conchonius）为实验材料，通过半致死浓度（LC50）、性腺指数以及组织病理学指标对壬基酚（NP）的毒性进行了评价.结果表明，在半静止条件下，壬基酚对成体玫瑰无须96 h的LC50为（1 .72 ± 0 .06） μmol/L；在亚急性毒性（0 .17、0 .34和0 .68 μmol/L）下成体玫瑰无须暴露于壬基酚21 d后，其精巢指数（TSI）与卵巢指数（OSI）显著降低，并具有明显的剂量-效应关系；同时精巢与卵巢也发生了明显的组织病理学变化，精巢中支持细胞增生、生殖细胞数量减少；卵巢中卵泡发育迟缓、闭锁现象增加.结果说明壬基酚对玫瑰无须的雌、雄性腺均具有毒性效应，干扰了精卵的发育成熟.另外，玫瑰无须对壬基酚具有较高的敏感性，也是评价壬基酚毒性的一种理想模式鱼类. |
| 英文摘要 |
| Acute and sub-acute toxicities of nonylphenol (NP) on fish were investigated with adult rosy barb (Puntius conchonius). The acute toxicity of NP to adult rosy barb was determined in semi-static bioassays. Median lethal concentration (LC50) value of NP was (1 .72± 0 .06) μmol/L for 96 h exposure. The effects of sub-toxicity of NP (0 .17, 0 .34 and 0 .68 μmol/L) on the adult rosy barb were studied after 21 d exposure. It showed that testis somatic index (TSI) and ovary somatic index (OSI) were reduced significantly by NP in a dose-dependent manner. The histopathological examination showed that the gland structures were impaired by NP as evidenced by hypertrophied Sertoli cells, a loss of germinal cells in testis, retardation of eggs development and increase in atresia in the follicles of ovary. These suggest that NP exerts adverse effects on the testis and the ovary, and disturbs the development of sperm and eggs. In addition, due to rosy barb high sensitivity to NP, it is also possible to apply rosy barb as a potential fish model to the toxicity of NP. |
