| 硒拮抗汞污染的粮食诱导大鼠中枢神经系统c-fos基因表达 |
| 摘要点击 1984 全文点击 1845 投稿时间：2004-04-04 修订日期：2004-07-13 |
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| 中文关键词 硒 汞 拮抗效应 c-fos |
| 英文关键词 selenium mercury antagonistic effects c-fos |
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| 中文摘要 |
| 为了从分子水平探讨硒与汞的拮抗效应和不同形态汞对脑的损伤 ,应用RT PCR方法和免疫组织化学方法研究了大鼠在汞污染粮食诱导下脑中c-fos mRNA表达和c-FOS蛋白表达 .结果表明 ,汞污染粮食能够显著诱导大鼠脑c-fos mRNA表达和c-FOS蛋白表达 ;硒能够拮抗汞在脑中的蓄积水平 ;硒能够拮抗汞诱导c-fos表达 .同时分析了硒汞拮抗的分子机制 . |
| 英文摘要 |
| The objective of this paper is to study the antagonisms between selenium and mercury and the effect of different species mercury on the brain injury. The expression of c-fos mRNA and c-FOS protein in rat brain induced by Hg-contaminated rice was observed by using reverse transcriptions polymerase chain reaction (RT-PCR) and immunocytochemical methods. The results show the Hg-contaminated rice induced significantly the expression of c-fos mRNA and c-FOS protein; selenium could antagonize mercury accumulative level in brain. Antagonistic effects of selenium on the expression of c-fos included by mercury and the molecule mechanism of the antagonisms between selenium and mercury was probed, too. |
