| 氯化甲基汞对大鼠脑c-fos和c-jun基因表达的影响 |
| 摘要点击 1438 全文点击 1482 投稿时间：2002-01-11 修订日期：2002-06-14 |
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| 中文关键词 氯化甲基汞 c-fos c-jun 基因表达 |
| 英文关键词 methylmercury chloride c-fos c-jun gene expression |
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| 中文摘要 |
| 为了研究即刻早期基因c-fos、c-jun在氯化甲基汞(MMC)神经毒性机制中的作用,本研究应用免疫组织化学方法对皮下注射甲基汞5.0mg/kg及0.1mg/kg的大鼠脑区FOS、JUN表达水平进行观察,对照组注射生理盐水.结果表明,急性暴露3h后,暴露组大鼠脑FOS、JUN蛋白表达均高于对照组,从而表明即刻早期基因(IEG)参与了氯化甲基汞对中枢神经系统损害的毒性过程. |
| 英文摘要 |
| To study the role of immediate early genes (IEG) c-fos and c-jun in the neurotoxic mechanism of methylmercury chloride(MMC), expression of FOS and JUN in rat brains was observed by using immuohistochemical methods. In the test group MMC (5.0mg/kg and 0.1mg/kg ) was injected into rats while in the control group normal saline was injected. The results showed that after rats exposed for 3 hours, the expression of FOS and JUN in brains was higher than those of the control rats, the results indicated that IEG could participate in the neurological toxicity induced by chlorimethylmercury. |
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