| 多种农药对胎儿发育的联合作用分析 |
| 摘要点击 630 全文点击 1163 修订日期：1993-04-05 |
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| 中文关键词 农药 妊娠结局 交互作用 联合影响 |
| 英文关键词 pesticide pregnancy outcome interaction combined effect |
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| 中文摘要 |
| 分析了应城农村12万确定人群中1988-1989年2年期间出现妊娠结局的妇女的前瞻性流行病学调查资料。共调查了5674位妇女。按照孕期家中使用的农药品种数目,将研究对象分为0、1、2、3、4、5、≥6和总暴露组,计算了各组发生各种不良妊娠结局的相对危险度,结果表明。所暴露的农药品种数愈多,发生自然流产和出生缺陷的危险度愈大。农药品种数与它们对胎儿发育的不良影响之间存在"剂量-效应关系".由此得出结论;多种农药的同时使用可能发生交互作用,而这种对胎儿发育的不良联合效应对较早期的妊娠尤为明显。 |
| 英文摘要 |
| In this paper analysed are the data from a prospective epidemiological investigation on women whose pregnancy outcomes occurred during the period 1988-1989 in a defined rural populstion (about 120000 in total) in Yingchen county. There were 5674 women studied. According to the numbers of the pesticides which had ever been used by their families during their gestation period, the subjects were classified into eight cohorts and the relative risks for occurring various adverse presnancy outcomes of each cohort were calculated.The results showed that the more the numbers of pesticider exposed, the more the risk for occurring spontaneous abortion and birth defect. There might be existed dose-response relationship between the numbers of pesticide categories and the adverse effects on fetal development. It is concluded that multiple pesticides used simultaneousely could have interacted with each other. Such combined effects were more significant during the earlier stage of pregnancy. |
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