| 水中有机物致大骨节病的实验研究 |
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| 英文关键词 |
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| 中文摘要 |
| 大骨节病(Kaschin-Beck disease)至今原因不明。在众多病因学说中,饮水有机物中毒说,粮食霉菌感染说和地球生物化学说较为受到重视。但都因流行病学研究和环境生态学考察结果不一致,更因缺少实验论证而未为人们所确认。 |
| 英文摘要 |
| This paper introduces briefly the results of patho-geny of Kaschin-Beck disease (KB) which the authors have researched into for many years. (1) In KB zone, there exists humic substance in drinking water, which causes the damage of chondrocytes in vitro. As water quality was improved and the substance lessened, the incidence of KB disease in the residents had dropped and the effects of chondrocyle damage became lower; (2) Selenium can be used to prevent chondrocyte damage caused by humic substance. This result corresponds to the disease that probably occurs in the zone of low selenium nutrition. (3) Cereal and humic substance in the KB zone has caused GBH-Px activity of rat blood decreasing. (4) The initial results showed that hydroxyl group of the organic compound might affect chondrocyte damage. |
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