| 3种典型消毒副产物对细菌抗生素抗性的影响 |
| 摘要点击 3568 全文点击 1580 投稿时间：2014-12-20 修订日期：2015-01-20 |
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| 中文关键词 消毒副产物 抗生素抗性 基因突变 三卤甲烷 卤乙酸 醛类 |
| 英文关键词 disinfection byproducts (DBPs) antibiotic resistance gene mutagenesis trihalomethanes (THMs) haloacetic acids (HAAs) aldehydes |
| 作者 | 单位 | E-mail | | 吕露 | 中国科学院城市环境研究所, 城市环境与健康重点实验室, 厦门 361021 | llv@iue.ac.cn | | 张梦露 | 中国科学院城市环境研究所, 城市环境与健康重点实验室, 厦门 361021 | | | 王春明 | 中国科学院城市环境研究所, 城市环境与健康重点实验室, 厦门 361021 | | | 林惠荣 | 中国科学院城市环境研究所, 城市环境与健康重点实验室, 厦门 361021 | | | 于鑫 | 中国科学院城市环境研究所, 城市环境与健康重点实验室, 厦门 361021 | xyu@iue.ac.cn |
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| 中文摘要 |
| 本文研究了消毒副产物对细菌抗生素抗性的作用. 分别选取三卤甲烷类(THMs)、卤乙酸类(HAAs)以及醛类消毒副产物中典型物质一氯二溴甲烷(CDBM)、碘乙酸(IAA)和水合三氯乙醛(CH),研究了细菌经消毒副产物染毒之后,对多种抗生素的抗性变化情况. 结果发现, 3种消毒副产物均可以诱导野生型铜绿假单胞菌提高对5种受试抗生素的抗性,提高作用IAA>CH>CDBM. IAA对多重抗性也具有一定的提高作用. 野生型大肠杆菌的抗生素抗性同样能够被DBPs诱导提高,说明DBPs对抗性的影响具有普遍性. 其作用机制可能是DBPs通过氧化胁迫机制诱导细菌发生突变,进而提高细菌抗生素抗性. 本研究表明饮用水系统中部分细菌抗生素抗性的获得可能与消毒副产物有关; 除毒理学风险外,消毒副产物的流行病学风险同样不容忽视. |
| 英文摘要 |
| The effect of typical disinfection byproducts (DBPs) on bacterial antibiotic resistance was investigated in this study. chlorodibromomethane (CDBM), iodoacetic acid (IAA) and chloral hydrate (CH) were selected, which belong to trihalomethanes (THMs), haloacetic acids (HAAs) and aldehydes, respectively. After exposure to the selected DBPs, the resistance change of the tested strains to antibiotics was determined. As a result, all of the three DBPs induced Pseudomonas aeruginosa PAO1 to gain increased resistance to the five antibiotics tested, and the DBPs ranked as IAA> CH> CDBM according to their enhancement effects. Multidrug resistance could also be enhanced by treatment with IAA. The same result was observed in Escherichia coli K12, suggesting that the effect of DBPs on antibiotic resistance was a common phenomenon. The mechanism was probably that DBPs stimulated oxidative stress, which induced mutagenesis. And the antibiotic resistance mutation frequency could be increased along with mutagenesis. This study revealed that the acquisition of bacterial antibiotic resistance might be related to DBPs in drinking water systems. Besides the genotoxicological risks, the epidemiological risks of DBPs should not be overlooked. |
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