| 广东典型海水养殖区沉积物及鱼体中磺胺类药物的残留及其对人体的健康风险评价 |
| 摘要点击 3020 全文点击 1879 投稿时间：2013-12-02 修订日期：2014-02-24 |
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| 中文关键词 广东沿海 磺胺类抗生素 海洋养殖 污染 风险评价 |
| 英文关键词 coast of Guangdong Province sulfonamides(SAs) marine aquaculture pollution risk assessment |
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| 中文摘要 |
| 采用高效液相色谱-紫外检测器（HPLC-UV）分析了广东沿海大亚湾和阳江两个典型海水养殖区中沉积物以及7种养殖鱼类肌肉和肝脏组织中磺胺嘧啶（SDZ）、磺胺二甲嘧啶（SM2）和磺胺甲基异 唑（SMX）的残留量，并依据药品最高残留量（MRL）值和每日允许摄入量（ADI）值对海水养殖鱼类中磺胺类抗生素污染进行人体健康风险评价. 结果表明，在所有沉积物样品中都能检出磺胺类抗生素. 含量（干重）范围为： 2.1~35.2 ng·g-1，检出率大小顺序为SDZ （85.7%）>SM2 （71.4%）>SMX （28.6%）. 大亚湾养殖区磺胺药物在沉积物和鱼类样品中的检出频率大于阳江养殖区. 3种磺胺类药物在鱼肝脏组织中的含量显著高于在肌肉组织中的含量 （P<0.05）. SDZ、SM2和SMX在鱼体肌肉组织中的含量（湿重）范围分别为11.6~37.9、16.3~27.8和4.9~20.0 ng·g-1. 3种磺胺类药物的平均日摄入量范围为3.37~36.72 ng·kg-1，仅占食用肉类ADI的最高限值（50 μg·kg-1）的0.007%~0.073% （<1% ADI），健康风险为可以忽略，膳食安全性高. |
| 英文摘要 |
| Concentrations of sulfonamides including sulfadiazine (SDZ), sulfadimidin (SM2) and sulfamethoxazole (SMX) in sediments, muscle and liver tissues of 7 kinds of fish species collected from two marine aquaculture regions along the coast of Guangdong Provice were determined by high performance liquid chromatography (HPLC) equipped with a ultraviolet detector. Assessment of the health risks were conducted based on the values of maximum residue limits (MRL) and acceptable daily intake (ADI). The results showed that sulfonamides were found in all the sediment samples. The concentrations (dry wet) ranged from 2.1-35.2 ng·g-1, the detected frequency of the 3 sulfonamide antibiotics ranked as SDZ (85.7%)>SM2(71.4%)>SMX (28.6%). The detection rate of sulfonamides in samples from Daya Bay was higher than that from Hailing Island. Higher concentrations were detected in liver tissues rather than in muscle tissues (P<0.05). The residues of SDZ, SM2 and SMX in fish muscle tissues (wet weight) ranged from 11.6-37.9, 16.3-27.8 and 4.9-20.0 ng·g-1, respectively. The calculated daily intakes of sulfonamides in the present study ranged from 3.37-36.72 ng·kg-1, which accounted for 0.007%-0.073% of the ADI (50 μg·kg-1). Health risks to human body were negligible as the estimated intake was less than 1% ADI, therefore the security of dietary was high. |
