| 基于污水监测比较海口市与五指山市槟榔消费的时空差异 |
| 摘要点击 240 全文点击 6 投稿时间：2025-03-08 修订日期：2025-05-12 |
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| 中文关键词 槟榔碱 污水流行病学 槟榔消费 海南省 质谱分析 |
| 英文关键词 arecoline wastewater-based epidemiology areca nut consumption Hainan Province mass spectrometry analysis |
| DOI 10.13227/j.hjkx.202503086 |
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| 中文摘要 |
| 槟榔作为一种合法的中药材，同时亦具备成瘾性，其消费量在我国逐年上升，并与多种疾病的发生具有显著相关性，引起了学术界的广泛关注. 通过构建实时监测槟榔消费的方法对于控制与健康相关的风险具有至关重要的意义. 污水流行病学因其低成本、高时效性和检测准确性，在监测成瘾性物质方面已得到广泛应用，但有关槟榔消费的研究仍显不足. 基于上述背景，根据污水流行病学方法，对海口市与五指山市19座污水处理厂进水样本进行了动态采集并测定5种槟榔碱及其代谢产物，探析其时空分布规律. 结果显示，海口市污水处理样本中普遍检出槟榔标志物，且千人日均负荷量表现出冬季高于夏季、节假日显著升高的趋势；生活污水中的标志物质量浓度显著高于工农业污水；海口市不同时间与空间样本中4种槟榔碱代谢物的比例未见显著差异，但槟榔次碱和1-甲基哌啶-3-羧酸的占比显著低于五指山市，表明两个城市间人群的槟榔消费模式存在差异. 综上，基于污水中槟榔碱标志物的质量浓度及其组成差异能有效反演区域人群对槟榔制品消费特征，在公共卫生学意义上有望发展成为槟榔消费与健康风险监测和评估的关键技术体系. |
| 英文摘要 |
| Areca nut is a legal but addictive substance. Its consumption is rising in China and is closely linked to various diseases. This has raised widespread concern. It is crucial to develop real-time monitoring methods for areca nut consumption. Wastewater-based epidemiology is a low-cost， timely， and accurate method. It has been widely used to monitor addictive substances. However， research on areca nut remains limited. Based on the background above， areca nut biomarkers from the biomarkers of 19 wastewater treatment plants in Haikou and Wuzhishan over a six-month period were collected and analyzed. The results revealed clear spatiotemporal patterns of areca nut consumption. Areca nut biomarkers were consistently present in city sewage. Per capita load was higher in winter than in summer， with noticeable increases during holidays. The concentration of these biomarkers was markedly higher in domestic sewage compared to that in industrial or agricultural sewage. Furthermore， the composition ratios of four areca nut biomarkers showed little variation over time or across locations within Haikou. In contrast， the proportions of arecoline and N-methylnipecotic acid notably were lower than those observed in Wuzhishan. This reflects differences in areca nut consumption habits between the two cities. In conclusion， wastewater-based epidemiology of areca nut biomarkers can effectively reflect local consumption levels and habits. This provides a reliable tool for monitoring areca nut use. |
