| 三丁基锡在水-脂质体间的分配行为 |
| 摘要点击 2634 全文点击 1998 投稿时间：2001-06-20 修订日期：2001-12-02 |
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| 中文关键词 三丁基锡 正辛醇水分配系数 脂质体 pH |
| 英文关键词 tributyltin octanol water partition coefficient liposome pH |
| DOI 10.13227/j.hjkx.20020420 |
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| 中文摘要 |
| 测定了不同酸度条件下三丁基锡(TBT)的正辛醇-水分配系数,并用卵磷脂自行制备脂质体代替正辛醇研究了TBT在人工合成生物膜-水间的分配行为.结果表明TBT在正辛醇和脂膜中的分配均随pH的增大而增大.但将二者进行比较,发现在pH＞pKa时,TBT在二者中的分配比很接近,此时是疏水性TBTOH占优势;但在低pH下,TBT+是主要存在形态,其在脂膜中的分配量要大于在正辛醇中的分配量,说明此时用正辛醇来模拟三丁基锡在生物膜中的分配是不合适的.对离子型有机金 |
| 英文摘要 |
| Distribution of the tributyltin (TBT) between egg phosphatidylcholine membranes (liposome) and water under different pH and a comparison between the partition of TBT into lipid membranes and into octanol were studied. The distribution of this compound into both lipid membranes and octanol increased with pH. The major difference was that at lower pH, where ionized TBT dominated distribution was greater into lipid membranes compared to that of octanol. At high pH, where TBT predominates as neutral species, the distribution ratios were very similar in the octanol and the liposome water system. These differences can be attributed to the properties of the biomembrane. The results indicated that the liposome water partition model appears to be a better molecular descriptor for ionogenic organic compounds. |
