| 汞污染粮食诱导大鼠海马c-FOS蛋白表达 |
| 摘要点击 1398 全文点击 1152 投稿时间：2004-03-17 修订日期：2004-06-23 |
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| 中文关键词 汞污染粮食 c-fos 基因表达 海马 早期预报 |
| 英文关键词 mercury contaminated rice c-fos gene expression hippocampus early prediction |
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| 中文摘要 |
| 为了探讨我国典型汞污染地区汞污染生物效应 ,并尝试应用即刻早期基因c-fos表达变化早期预报典型汞污染地区汞神经毒性的可行性 ,本文应用免疫组织化学方法研究了实验粮食饲喂后 ,大鼠海马c-FOS蛋白表达变化 .结果表明污染粮食显著诱导大鼠海马c-FOS蛋白表达 ;在饲喂过程中硒与汞有拮抗效应 .初步推断 ,即刻早期基因c-fos表达变化可以作为汞污染地区汞神经毒性检测和评价效应指标 . |
| 英文摘要 |
| In order to probe into the biological effects of mercury in typical mercury contaminated area and try to apply the expression of immediately early gene c-fos in brain to early predict the neurotoxicity of mercury in typical polluted areas, the expression of c-FOS protein in rat hippocampus is observed using immunocytochemical methods. The results show the mercury pollutes rice induced significantly the expression of c-FOS protein in hippccampus;the antagonisis between selenium and mercury on the exposure process. It is suggested that c-fos can be used as an effective index of detecting and assessing neurotoxicology of mercury polluted areas. |
