| 狗尿中1-羟基芘鉴定和排出规律 |
| 摘要点击 834 全文点击 647 投稿时间：1990-05-30 |
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| 中文关键词 狗 尿 1-羟基芘 |
| 英文关键词 identification of 1-hydroxypyrene pyrene dog urine |
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| 中文摘要 |
| 经高压液相色谱分离,萤光光谱法鉴定,狗肌肉注射芘后尿中的代谢产物为1-羟基芘。分别给狗1、2、5μmol/kg芘后,尿中排出的1-羟基芘均以第24-48h期间最高;尿中排出的1-羟基芘约占注入芘的0.05%左右。 |
| 英文摘要 |
| With High Performance Liquid Chromatograph and fluorospectrometry, 1-hydroxypyrene is identified as a major metabolite of pyrcne in the dog urine after intra-musculary injection of pyrene. As three successive doses of 1, 2 and 5 μmol/kg. wt pyrene were injected into the dogs, 1-hydroxypyrcne in urinary excretion reached to peak levels within 24-48 hours. The amounts of excreted 1-hydroxypyrene were accounted for about 0.05% of the injected pyrene. |
